Has Donna always been that much bigger than Frankie, and I just never noticed?
There aren't many pictures in this series that give you a good chance to compare their sizes. Most times, they are both seated, or one is much closer to the viewer than the other. But this pic shows Donna as roughly a head taller than Frankie. And Donna is kind of slumping in it. http://www.cutloosecomic.com/archive/comic/2016/10/24 So yeah, Mouse vs Lynx - the size difference has always been there.
Little mousie is about to be eaten.
Moving Day - Page 06 Rough Sketch
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The Original Trio
Frankie - by Tikiman